Post-transcriptional regulation of gene expression by degradation of messenger RNAs
نویسندگان
چکیده
منابع مشابه
Post-Transcriptional Regulation of Papillomavirus Gene Expression
Papillomavirus genomes are transcribed as one large complex transcription unit with multiple promoters, two poly(A) sites (early and late), and considerable alternative splicing. As a result, there are multiple opportunities for post-transcriptional regulation of papillomavirus gene expression. Although this area has not been as extensively studied as transcriptional regulation, there are a few...
متن کاملHuman ADAM33 messenger RNA expression profile and post-transcriptional regulation.
We examined transcript expression and post-transcriptional regulation of human ADAM33, a recently identified asthma gene. A detailed messenger RNA (mRNA) expression profile was obtained using Northern, reverse transcription polymerase chain reaction, and in situ hybridization analyses. ADAM33 mRNA was expressed significantly in smooth muscle-containing organs, minimally in immune organs and hem...
متن کاملCell-Specific Post-Transcriptional Regulation of γ-Synuclein Gene by Micro-RNAs
γ-Synuclein is a member of the synucleins family of small proteins, which consists of three members:α, β- and γ-synuclein. γ-Synuclein is abnormally expressed in a high percentage of advanced and metastatic tumors, but not in normal or benign tissues. Furthermore, γ-synuclein expression is strongly correlated with disease progression, and can stimulate proliferation, induce invasion and metasta...
متن کاملPost-transcriptional regulation of pro-inflammatory gene expression
The cytokine tumour necrosis factor (TNF)alpha is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in rheumatoid arthritis is illustrated by the clinical benefits of TNF alpha blockade. Post-transcriptional regulation (the control of mRNA stability and translation) appears to play a critical role in the regulation of TNF alpha exp...
متن کاملTranscription and post-transcriptional regulation of avian HSP70 gene expression.
Transient incubation of chicken lymphoblastoid (MSB) cells at elevated temperatures induces the synthesis of three heat shock proteins of 89,000 Da (HSP89), 70,000 Da (HSP70), and 23,000 Da (HSP23). We have examined the effects of heat shock on the transcription and post-transcriptional regulation of the chicken HSP70 and beta-actin genes. The rate of HSP70 transcription is rapidly induced by h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2003
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.10272